Drug delivery

A method of drug delivery to tissue, comprising:

• inserting into a bodily conduit a catheter such that the catheter is placed adjacent to tissue to be treated, the catheter defining a central lumen;
• the catheter comprising energy-emitting source disposed within the central lumen of the catheter;
• inflating the compression balloon with a warmed fluid to a pressure sufficient to expand the bodily conduit and compress the tissue to be treated;
• the inflating including circulating the warmed fluid through the compression balloon and then out of the compression balloon and into the central lumen of the catheter where the energy-emitting source is disposed;
• providing a drug encapsulated within a heat-sensitive liposome;
• and
• preferentially heating with the energy-emitting source the tissue to be treated to destroy at least a portion of the tissue to be treated and also to activate the heat-sensitive liposome to release the encapsulated drug such that the drug targets the tissue to be treated;
• the preferentially heating including the steps of
• applying a shielding material to at least a portion of the catheter or the compression balloon to absorb the emitted energy;
• and
• electrically grounding the shielding material to dissipate the absorbed energy.