Melanin-concentrating hormone receptor antagonists and methods of use

A composition of matter comprising a compound having the following structural formula:

• wherein,
• R1 and R2 are selected from H, a hydrocarbyl having up to 20 carbon atoms, and a hydrocarbyl having up to 20 carbon atoms and substituted with a group selected from hydroxy, alkoxy, amino, substituted amino, thio, alkylthio, guanidino, ureido and heterocyclyl;
• R3 is selected from a hydrocarbyl having up to 20 carbon atoms, and a hydrocarbyl having up to 20 carbon atoms and substituted with a group selected from halo, haloalkyl, hydroxy, alkyl, alkoxy, alkylenedioxy, amino, substituted amino, aminoalkyl, thio, alkylthio, guanidino, ureido, heterocyclyl, heteroaryl, and heteroarylthio;
• R4 is a substituted amino, —NR6R7, wherein R6 and R7 are selected from H and a hydrocarbyl having up to 20 carbon atoms;
• R6 and R7, with inclusion of N, may combine to form a heterocyclic ring such as indolinyl having the formula
• R5 is selected from O, S, NH, N-alkyl, N-alkenyl, N-alkynyl, N-cycloalkyl, N-aryl and N-aralkyl,
• n is 1 to 3;
• and
• wherein the composition is further characterized by at least one additional limitation selected from group consisting of:
• one or more methylene groups of a hydrocarbyl group of R3 being replaced by an oxygen atom;
• R1 being selected from alkyl and aminoalkyl;
• R1 being selected from (S)-Methyl, (R)-Methyl or (S)-Propyl;
• R1 being (S)-Aminopropyl;
• R2 being selected from (R)-Aminomethyl-(imino)-propyl, (S)-Aminomethyl-(imino)-propyl or (S)-Methylthiomethyl;
• R3 being selected from alkyl, aralkyl or substituted aralkyl;
• R3 being 3-bromophenethyl;
• R3 being 3,5 bis-(trifluoromethyl)phenethyl;
• R4 being aralkylamino;
• R4 being benzylamino;
• R6 and R7 with inclusion of n, being heterocyclyl;
• and
• —NR6R7 being isoindolinyl having the formula