Fc variants with altered binding to FcRn
AssigneeXencor, Inc.
InventorsAaron Keith Chamberlain, Bassil I. Dahiyat, John R. Desjarlais, Sher Bahadur Karki, Gregory Alan Lazar
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Abstract
The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.
Claims3
An antibody comprising a variant Fc region of a parent Fc polypeptide wherein said variant Fc region comprises a tyrosine at position 252 and a leucine at position 428, wherein said antibody is selected from the group consisting of a chimeric antibody, a humanized antibody and a human antibody, and wherein numbering is according to the EU Index in Kabat et al.
Dependencies are inferred from the claim text.