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US 8,367,635 B2Granted
Antimicrobial sucralfate paste methods and compositions
OwnerPatrick D. McGrathinventor
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Abstract
Methods for the prevention and treatment of infection, preferably antibiotic resistant wound infection, using a paste formed by the reaction of sucralfate with an acid component are provided. Methods of preparing stable sucralfate compositions are disclosed. Compositions of and products containing the sucralfate paste are also described.
Claims5
A method of preparing a stable sucralfate composition comprising:
- providing a source of sucralfate;
- reacting the sucralfate with an acid component to form a stable composition comprising a paste and a supernatant, wherein the acid component reacted exceeds 8 millimoles per 5 grams of sucralfate;
- and
- allowing the paste to remain in contact with the supernatant for at least about 18 hours so as to increase the pH of the supernatant to about 3 or higher.
1 more element
Dependencies are inferred from the claim text.