Carbon nanotube structures in sensor apparatuses for analyzing biomarkers in breath samples
AssigneeTechnion Research & Development Foundation Limited
InventorsHossam Haick, Peng Gang
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Abstract
The present invention provides a system for measuring biomarker analytes indicative of various diseases comprising an array of sensors sensitive to volatile organic compounds. Particularly, the system is composed of a random network of single-walled carbon nanotubes (SWCNTs) coated with non-polar small organic molecules in conjunction with learning and pattern recognition algorithms. Methods of discriminating between breath samples of healthy individuals and of lung cancer patients are disclosed.
Claims22
A system for detecting volatile organic compounds derived from a breath sample, the system comprising:
- (a) an apparatus comprising an array of chemically sensitive sensors of single walled carbon nanotubes coated with non-polymeric, non-polar small organic molecules, wherein the organic molecules comprise functional groups selected from the group consisting of alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heterocyclyl, heteroaryl, alkylaryl, alkylalkenyl, alkylalkynyl, alkylcycloalkyl, alkylheterocyclyl, and alkylheteroaryl groups, and combinations thereof, wherein the functional groups are unsubstituted or substituted by at least one of a carboxyl, an acyl, an amido, an ester, a nitro, an azido, a halogen, a hydroxyl or a haloalkyl moiety;
- and
- (b) a processing unit comprising a learning and pattern recognition analyzer wherein the learning and pattern recognition analyzer receives sensor output signals from the apparatus and compares them to stored data.
Dependencies are inferred from the claim text.