# US 8,366,620 B2 · Methods and apparatus for intracranial ultrasound delivery

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- Number: US 8,366,620 B2
- Document ID: US8366620B2
- Status: Granted
- Kind: B2
- Application number: 12/799,706
- Filed: 2010-04-30
- Published: 2010-09-02
- Granted: 2013-02-05
- Earliest claimed: 2005-06-24
- Applicants: Henry Nita
- Inventors: Henry Nita
- Web page: https://patentgrep.com/patent/US8366620B2

## CPC

- A61N 7/00: Ultrasound therapy (lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 {; using ultrasound for introducing media into the body A61M37/0092})
- A61N 7/022: {intracavitary}
- A61B 8/0808: {for diagnosis of the brain}
- A61B 90/11: with guides for needles or instruments, e.g. arcuate slides or ball joints
- A61B 2017/22008: {used or promoted}
- A61N 2007/0047: {interstitial}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

A method for delivering ultrasound energy to a patient's intracranial space involves forming at least one hole in the patient's skull, advancing at least one ultrasound delivery device at least partway through the hole(s), and transmitting ultrasound energy from the ultrasound delivery device(s). According to various embodiments, ultrasound delivery devices may be advanced into the epidural space, one or both ventricles and/or an intracerebral space of the patient's brain. In alternative embodiments, one or multiple holes may be formed in the skull, and any number of ultrasound delivery devices may be used. Intracranial ultrasound delivery may be used in diagnostic or therapeutic treatment of ischemic stroke, head trauma, atherosclerosis, perfusion disorders and other acute or chronic neurological conditions.

## Claims

### Claim 1

A method for delivering ultrasound energy to a patient's intracranial space, the method comprising:
forming at least one hole in the patient's skull to access a target location;
placing an introducer device into the at least one hole to a treatment location within the target location;
advancing at least one ultrasound device having a distal portion through the introducer device, wherein the distal portion of the ultrasound device contains at least one transducer to allow transmission of ultrasound, and the distal portion can be moved to various locations within the intracranial space;
positioning the distal portion at a selected location within the intracranial space;
transmitting ultrasound energy at frequencies between 10 KHz and 10 MHz from the ultrasound device for therapeutic treatment; and
transmitting and directing the ultrasound energy to a blood clot in the patient's brain at the target location that resides in an intracranial space of the patient's brain, wherein the blood clot is located outside a blood vessel.

### Claim 2 (depends on 1)

The method of claim 1, wherein the blood clot resides in the intracerebral location of the intracranial space.

### Claim 3 (depends on 1)

The method of claim 1, wherein the blood clot resides underneath the dura mater located within the intracranial space.

### Claim 4 (depends on 1)

The method of claim 1, wherein the blood clot resides in the epidural location of the intracranial space.

### Claim 5 (depends on 1)

The method of claim 1, wherein advancing the at least one ultrasound device comprises advancing the device into the patient's epidural space.

### Claim 6 (depends on 1)

The method of claim 1, wherein advancing the at least one ultrasound device comprises advancing the device into at least one ventricle of the patient's brain.

### Claim 7 (depends on 1)

The method of claim 1, wherein advancing the at least one ultrasound device comprises advancing the device into an intracerebral space of the patient's brain.

### Claim 8 (depends on 1)

The method of claim 1, wherein advancing the at least one ultrasound device comprises advancing the device underneath the dura mater of the patient's brain.

### Claim 9 (depends on 1)

The method of claim 1, wherein advancing the ultrasound device comprises advancing a device selected from the group consisting of an ultrasound transducer and a transducer-tipped ultrasound catheter.

### Claim 10 (depends on 1)

The method of claim 1, further comprising delivering at least one pharmacologic agent to the patient intracranial space.

### Claim 11 (depends on 1)

The method of claim 1, further comprising delivering microbubbles or nanobubbles.

### Claim 12 (depends on 1)

The method of claim 1, further including removing blood clots to the outside the head.