Foamable vehicle and pharmaceutical compositions thereof
AssigneeFoamix Ltd.
InventorsDov Tamarkin, Doron Friedman, Meir Eini, Alex Besonov
Life of this patent
Estimating the term…
Abstract
A hygroscopic pharmaceutical composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of at least 0.9 and an antiinfective agent. A foamble pharmaceutical carrier includes about 50% to about 98% of a polar solvent selected from the group consisting of a polyol and PEG; 0% to about 48% of a secondary polar solvent; about 0.2% to about 5% by weight of a surface-active agent; about 0.01% to about 5% by weight of at least one polymeric agent; and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
Claims18
A foamable hygroscopic pharmaceutical composition in a pressurized container, the foamable hygroscopic pharmaceutical composition comprising:
- i) a carrier composition comprising:
- a. at least one hygroscopic substance selected from the group consisting of:
- a polyethylene glycol (PEG) and a polyol at a sufficient concentration to provide an Aw value of the hygroscopic pharmaceutical composition of less than 0.9;
- b. about 0.01% to about 5% by weight of the carrier composition of a gelling agent;
- and
- c. 0% to about 25% by weight of the carrier composition of water;
- and
- ii) a liquefied or compressed gas propellant;
- wherein the foamable hygroscopic pharmaceutical composition forms a breakable foam upon release from the pressurized container;
- wherein the breakable foam does not immediately collapse upon exposure to skin temperature;
- and wherein the breakable foam breaks under shear force.
A foamable pharmaceutical carrier composition in a pressurized container comprising:
- i) a carrier composition comprising:
- a. about 50% to about 98% by weight of the carrier composition of a polar solvent selected from the group consisting of (1) a polyol and (2) a polyethylene glycol (PEG);
- b. 0% to about 48% by weight of the carrier composition of a secondary polar solvent;
- c. about 0.01% to about 5% by weight of the carrier composition of a gelling agent;
- and
- d. 0% to about 25% by weight of the carrier composition of water;
- and
- ii) a liquefied or compressed gas propellant;
- wherein the foamable pharmaceutical carrier composition forms a breakable foam upon dispensing from the pressurized container;
- wherein the breakable foam does not immediately collapse upon exposure to skin temperature;
- and wherein the breakable foam breaks under shear force.
Dependencies are inferred from the claim text.