Antibodies for the selective determination of procalcitonin 1-116
AssigneeB.R.A.H.M.S GmbH
InventorsAndreas Bergmann, Joachim Struck
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Abstract
The present invention provides an immunodiagnostic method for determining procalcitonin and procalcitonin derivatives in a biological sample of a patient for diagnostic purposes, in particular in the monitoring and control of treatment and the monitoring of the progression of a local or systemic bacterial infection, inflammation, sepsis or neurodegenerative disease. In particular, the method detects molecular forms of procalcitonin, or procalcitonin partial peptides derived therefrom, having the amino acids alanine and proline (Ala-Pro, AP) in positions 1 and 2 of the amino terminus of the complete procalcitonin 1-116 (SEQ ID NO: 1.) Also disclosed are antibodies and kits for carrying out such a method.
Claims4
An isolated antibody which specifically binds an epitope of procalcitonin 1-116, said epitope comprising amino acids 1 and 2 of procalcitonin 1-116, and binds selectively to intact procalcitonin 1 to 116 (SEQ ID NO:
- 1) or procalcitonin partial peptides comprising amino acids 1 and 2 of SEQ ID NO:
- 1, but does not bind to procalcitonin partial peptides that do not include amino acids 1 and 2 of SEQ ID NO:
- 1.
An isolated antibody which specifically binds a peptide consisting of the amino acid sequence of amino acids 1-9 of SEQ ID NO:
- 1, wherein said antibody binds selectively to intact procalcitonin1 to 116 (SEQ ID NO:
- 1) or procalcitonin partial peptides comprising amino acids 1 and 2 of SEQ ID NO:
- 1, but does not bind to procalcitonin partial peptides that do not include amino acids 1 and 2 of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.