Administering a biological composition or compositions isolated from self-renewing colony forming somatic cell growth medium to treat diseases and disorders

A method of administering a therapeutically useful amount of a biological composition or compositions to an organ, tissue, or subject, comprising:

• (a) isolating a biological composition or compositions from culture media in which an isolated population of bone marrow-derived self-renewing colony forming somatic cells (CF-SC) had been grown;
• and,
• (b) administering said biological composition or compositions to said organ, tissue, or subject,
• wherein said CF-SC do not have multipotent differentiation capacity, wherein said CF-SC have a normal karyotype, wherein said CF-SC are non-immortalized, and wherein said CF-SC are obtained from bone marrow by steps comprising:
• i) incubating bone marrow cells under a low oxygen condition such that said bone marrow cells when allowed to adhere to a tissue culture-treated surface produce adherent colony forming units;
• and,
• ii) passaging cells in said adherent colony forming units at low cell seeding densities.