# US 8,349,902 B2 · Pharmaceutical compositions useful for preventing and treating oncological diseases

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 8,349,902 B2
- Document ID: US8349902B2
- Status: Granted
- Kind: B2
- Application number: 12/524,961
- Filed: 2007-01-29
- Published: 2010-06-10
- Granted: 2013-01-08
- Earliest claimed: 2007-01-29
- Assignees: Mitotech SA
- Inventors: Vladimir P. Skulachev; Maxim V. Skulachev
- Web page: https://patentgrep.com/patent/US8349902B2

## CPC

- A61K 31/66: Phosphorus compounds
- A61K 31/4355: the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
- A61K 31/473: ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
- A61K 31/4741: condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
- A61K 47/54: the modifying agent being an organic compound
- A61K 47/545: {Heterocyclic compounds (A61K47/558 takes precedence)}
- A61P 35/00: Antineoplastic agents
- A61P 39/06: Free radical scavengers or antioxidants
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The invention relates to pharmacology, medicine and oncology, in particular, to a class of chemical compounds, the structure of which corresponds to formula (I) and which can be used in pharmaceutical compositions for preventing and treating an extended range of oncological diseases, including, in the form of an anti-tumoral preparation and a preparation which is used for combined therapy of oncological diseases.

## Claims

### Claim 1

A method of treating a cancer in a mammal selected from the group consisting of lung carcinoma, large intestine carcinoma, cervical carcinoma, skin carcinoma, colon cancer, Lewis carcinoma, fibrosarcoma, osteosarcoma, rhabdomyosarcoma, epithelial carcinoma, neuroblastoma, and lymphoma, comprising administering to the mammal a therapeutically effective amount of a pharmaceutical composition comprising the compound SkQ1 having the structure:
or a solvate or isomer thereof to said mammal,
where Z− is a pharmaceutically acceptable anion.

### Claim 2 (depends on 1)

The method of claim 1, wherein the pharmaceutical composition is administered with another anti-cancer therapeutic.

### Claim 3 (depends on 1)

The method of claim 1, wherein the pharmaceutical composition is a solution and is orally administered.

### Claim 4 (depends on 1)

The method of claim 1, wherein the pharmaceutical composition is a solution and is parenterally administered.

### Claim 5 (depends on 1)

The method of claim 1, wherein the pharmaceutical composition is an ointment, bandage, or film and is transdermally administered.

### Claim 6 (depends on 1)

The method of claim 1, wherein the cancer is a Ras-related metastatic cancer.