Method and pharmaceutical composition for improvement of wound healing
AssigneeCytoTools GmbH
InventorsKlaus J. Wannowius, Dirk Kaiser
Life of this patent
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Abstract
This invention relates to aqueous solutions of reactive chlorine compounds having the empirical formulae H2Cl2O6 or ClO3H, for example, and the derivatives, anions or salts thereof. The invention further relates to methods for the production of said compounds and the use thereof in the pharmaceutical and particularly in the medical field, in cosmetics, medicinal care and in the domains of food technology and technology.
Claims46
A method for the treatment of wounds comprising administering an aqueous solution of reactive chlorine compounds, wherein the aqueous solution is prepared by:
- (a) reacting chlorine dioxide with an aqueous solution of hydrogen peroxide or another hydroperoxide or peroxide at a pH value of ≧6.5, to produce a gaseous free reactive chlorine compound and a dissolved reactive chlorine compound,
- (b) lowering the pH value to 3 to 6 by adding an acid,
- (c) expelling the gaseous free reactive chlorine compound with a cooled gas and collecting the dissolved chlorine compound in a basic solution with a pH value of >10, and
- (d) incubating the collected dissolved reactive chlorine compound with up to 100-fold excess of chlorite at a pH value of 6 to 8.
An aqueous solution comprising reactive chlorine compounds, wherein the aqueous solution is prepared by:
- (a) reacting chlorine dioxide with an aqueous solution of hydrogen peroxide or another hydroperoxide or peroxide at a pH value of ≧6.5, to produce a gaseous free reactive chlorine compound and a dissolved reactive chlorine compound,
- (b) lowering the pH value to 3 to 6 by adding an acid,
- (c) expelling the gaseous free reactive chlorine compound with a cooled gas and collecting the dissolved chlorine compound in a basic solution with a pH value of >10, and
- (d) incubating the collected dissolved reactive chlorine compound with up to 100-fold excess of chlorite at a pH value of 6 to 8.
An aqueous solution comprising reactive chlorine compounds, the solution comprising a first reactive chlorine compound selected from the group consisting of dichloric acids of formula H2Cl2O6, anions thereof, and salts thereof, and the solution further comprising a second reactive chlorine compound selected from the group consisting of peroxochlorous acid of formula O═ClOOH, anions thereof, and salts thereof.
A pharmaceutical composition for treatment of wounds or enhancement of tissue regeneration comprising an effective dosage of an aqueous solution of reactive chlorine compounds, the solution comprising a first reactive chlorine compound selected from the group consisting of dichloric acids of formula H2Cl2O6, anions thereof, or salts thereof, and the solution further comprising a second reactive chlorine compound selected from the group consisting of peroxochlorous acid of formula O=ClOOH, anions thereof, and salts thereof.
Dependencies are inferred from the claim text.