Gamma-amino-butyric acid derivatives as GABAB receptor ligands
AssigneeXenoPort, Inc.
InventorsFeng Xu, Mark A. Gallop, Ge Peng, Thu Phan, Usha Dilip, David J. Wustrow
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Abstract
Gamma-amino-butyric acid derivatives that are GABAB receptor ligands, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives and pharmaceutical compositions thereof for treating diseases are disclosed.
Claims28
A compound of Formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is chosen from hydrogen and halogen;
- R2 is halogen;
- one of R3 and R4 is —X—Y, and the other of R3 and R4 is hydrogen, wherein:
- X is chosen from a covalent bond, C1-3 alkyldiyl, substituted C1-3 alkyldiyl, C1-3 heteroalkyldiyl, and substituted C1-3 heteroalkyldiyl;
- and
- Y is chosen from C6-12 aryl, substituted C6-12 aryl, C5-12 heteroaryl, and substituted C5-12 heteroaryl;
- and
- R5 is chosen from —COOH, —SOOH, and —P(O)(OH)R8 wherein R8 is chosen from hydrogen and C1-4 alkyl.
The compound (3R)-4-amino-3-[4-chloro-3-(4-pyridylmethoxy)phenyl]butanoic acid or a pharmaceutically acceptable salt thereof.
The compound 4-{5-[(1R)-2-amino-1-(carboxymethyl)ethyl]-2-chlorophenyl}thiophene-2-carboxylic acid or a pharmaceutically acceptable salt thereof.
The compound 5-15- R1R)-2-amino-1-(carboxymethyl)ethyl]-2-chlorophenyl}thiophene-3-carboxylic acid or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.