Antibiotic compositions for the treatment of gram negative infections
AssigneeBioSource Pharm, Inc.
InventorRichard A. Leese
Life of this patent
Estimating the term…
Abstract
Provided herein is an antibacterial compound of the following formula: or a pharmaceutically acceptable salt thereof. The antibacterial compound has antibacterial properties against a diverse range of gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin B. Also provided are antibacterial pharmaceutical compositions containing the antibacterial compound, as well as methods for preparing the antibacterial compound.
Claims15
A pharmaceutical composition comprising an antibacterial compound of the Formula:
- or a pharmaceutically acceptable salt thereof.
A method of treating a bacterial infection including a gram-negative bacteria, the method comprising administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising an antibacterial compound of the Formula:
- or a pharmaceutically acceptable salt thereof.
A process for preparing an antibacterial compound, the process comprising:
- (a) treating a polymyxin B with an amino protecting group comprising at least one acidic substituent to form a protected compound;
- (b) treating the protected compound with a deacylating agent, to form at least one deacylated protected compound;
- (c) treating the at least one deacylated protected compound with an isocyanate to form at least one acylated protected compound;
- and
- (d) treating the at least one acylated protected compound with an organic base to form the antibacterial compound having the Formula:
A compound of the Formula:
- or a salt thereof.
Dependencies are inferred from the claim text.