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US 8,343,491 B2Granted
Anti-HIMF antibodies to treat lung diseases
AssigneeThe Johns Hopkins University
InventorsRoger A. Johns, Qingning Su, Hunter Clay Champion
Life of this patent
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Abstract
Hypoxia induced mitogenic factor (HIMF) is a member of the “found in inflammatory zone” (FIZZ)/resistin family of proteins and has potent mitogenic, angiogenic, and vasoconstrictive effects in the lung vasculature. We use antibodies to HIMF to treat certain diseases including adult respiratory distress syndrome, radiation-induced pulmonary fibrosis, idiopathic pulmonary fibrosis, and emphysema.
Claims1
A method of treating a patient with Emphysema comprising:
- administering to the patient an antibody which specifically binds to HIMF (SEQ ID NO:1 or 2);
- whereby binding of HIMF to BTK is inhibited.
Dependencies are inferred from the claim text.