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US 8,342,737 B2Granted
Vibrational mixer
AssigneeSartorius Stedim Biotech GmbH
InventorsGerhard Greller, Oscar-Werner Reif
Life of this patent
Estimating the term…
Abstract
A vibrational mixer (1), in particular a single-path mixer for use in single-path bioreactors (4) with flexible walls, consisting of a mixer shaft (2) that can be set into longitudinal motions by a drive (8), with at least one mixing element (3), wherein at least one channel (13) is arranged in the mixer shaft with an opening to an interior reactor space (6).
Claims16
A vibration mixer (1) for use in disposable bioreactors (4, 4′) having a flexible wall, the vibration mixer comprising:
- a mixer stem (2, 2′) which can be thrown into longitudinal movements by a drive (8), at least one mixing element (3, 3′) mounted on the mixer stem (2, 2′), the mixer stem (2, 2′) being a tube with a free lumen (12, 12′) defining at least one first duct (13, 13′) having an inlet (14) external of the bioreactor (4, 4′) for delivering gas into the free lumen (12, 12′) and an outlet (16) toward a reactor interior (6, 6′) for delivering the gas into the bioreactor (4, 4′), and a tubular member or a hose (19) arranged in the free lumen (12, 12′) of the mixer stem (2, 2′) to define a second duct (20) in the mixer stem (2, 2′), the second duct (20) having an inlet external of the bioreactor (4, 4′) separated in a gas tight manner from the inlet (14) to the free lumen (12, 12′) of the first duct (13, 13′) and an outlet (21) in the bioreactor separated from the outlet (16) of the free lumen (12, 12′) of the first duct (13, 13′), the second duct (20) supplying media to the bioreactor (4, 4′) or removing media from the bioreactor (4, 4′).
A vibration mixer for use in a disposable bioreactor (4′) having a flexible wall, the vibration mixer comprising:
- a drive (8) disposed externally of the bioreactor (4′);
- a mixer stem (2′) having a first end connected to the drive (8), a second end in the bioreactor (4′) and a tubular outer wall extending substantially from the first end to the second end of the mixer stem (2′), at least one mixing element (3′) mounted on a portion of the tubular outer wall of the mixer stem (2′) in the bioreactor (4′) and an inner wall (19) disposed within the mixer stem (2′) to define a first duct (13′) and a second duct (20) in the mixer stem (2′), the first and second ducts (13′, 20) having inlets (14) external of the bioreactor (4′) that are separated from one another in a gas tight manner and outlets (16, 21) in the bioreactor (4′) separated from one another, whereby the first duct (13′) accommodates a supply of gas to the bioreactor (4′) and the second duct (20) enables media to be supplied to or removed from the bioreactor (4′).
Dependencies are inferred from the claim text.