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US 8,338,573 B2Granted
Crystal structure of CD147 extracellular region and use thereof
AssigneeZhinan Chen
InventorsZhinan Chen, Ping Zhu, Xiaoling Yu, Bin Yang, Xiangmin Yang, Zheng Zhang
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Abstract
A crystal, a preparation method and 3D structure of CD147 extracellular region are provided. Such 3D structure is useful in the determination of the active site of CD147 extracellular region by computer modeling or molecular docking method. The crystal and/or 3D structure are useful in a structure-based drug design and the selection of an antibody, a ligand or an interacting molecule of CD 147 extracellular region.
Claims4
A crystal of CD147 extracellular region, wherein the crystal has P41212 space group in a tetragonal crystal system and comprises amino acid sequence SEQ ID NO:
- 1, and is represented by a model which has a three-dimensional (3D) structure as in table 1, wherein the crystal has the following crystal lattice constants:
- a=126.481 ű0.5%, b=126.481 ű0.5%, c=169.926 ű0.5%, α=β=γ=90°, and there are four molecules in one asymmetric unit wherein the molecular weight of one molecule is about 20±0.5KD, and the solvent content of said crystal is about 70±1%.
Dependencies are inferred from the claim text.