Systems and methods for delivery of a therapeutic agent
AssigneeThe Foundry, LLC
InventorsMark E. Deem, Hanson Gifford
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Abstract
Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.
Claims21
A system for delivering toxins to target cells in a patient, said system comprising:
- a toxin consisting of a light chain of a neurotoxin fragment;
- a catheter or other structure adapted to introduce the toxin to a target region adjacent the target cells;
- and
- an energy applicator configured to apply energy from outside the body of the patient to the target cells at a level sufficient to cause pores to form in the cell membranes of the target cells to allow the toxin to pass through said pores into the target cells.
Dependencies are inferred from the claim text.