Chimeric poly peptides and the therapeutic use thereof against a Flaviviridae infection

A chimeric polypeptide comprising a subdomain of the E protein of Flaviviridae bound to a subdomain of the membrane M protein of Flaviviridae;

• wherein said chimeric polypeptide comprises an amino acid sequence selected from the group consisting of:
• amino acids 19 to 162 of SEQ ID NO:
• 3;
• amino acids 21 to 168 of SEQ ID NO:
• 6;
• amino acids 21 to 132 of SEQ ID NO:
• 12;
• amino acids 18 to 624 of SEQ ID NO:
• 20;
• amino acids 18 to 609 of SEQ ID NO:
• 21;
• amino acids 18 to 624 of SEQ ID NO:
• 22;
• amino acids 18 to 489 of SEQ ID NO:
• 23;
• and
• amino acids 21 to 474 of SEQ ID NO:
• 24.