Process for production of a betaine such as carnitine
AssigneeMitsubishi Rayon Co., Ltd.
InventorsKosuke Oishi, Eiji Sato, Hiroyuki Mori, Akira Yoshioka
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Abstract
According to the present invention, by using 4-halogeno-3-hydroxybutanamide as a substrate in quaternary amination reaction with trialkylamine which is an important step in betaine (such as carnitine) preparation processes, it becomes possible to reduce the production of crotonic acid derivatives (the major by-product) greatly compared to conventional processes. Consequently, it becomes possible to prepare a betaine, such as carnitine, at a high yield.
Claims13
A process for preparing a 4-trialkylamino-3-hydroxybutyramide halide represented by formula (2′) below:
- wherein A1, A2 and A3 are independent from each other, may be the same or different, and individually represent a C1-C20 hydrocarbon group which may have a substituent(s), and X1 is a halogen atom;
- said process comprising a step of quaternary aminating 4-halogeno-3-hydroxybutyramide represented by formula (2) below:
- wherein X1 is a halogen atom;
- with a trialkylamine represented by (NA1A2A3).
The process according to claim wherein said trialkylamine is trimethylamine.
Dependencies are inferred from the claim text.