Manufacturing apparatus of transdermal absorption preparation

A method for manufacturing a nicotine-containing transdermal absorption preparation, comprising:

• providing an adhesive sheet supplying part that feeds out a first adhesive sheet into a runway at a traveling speed, the adhesive sheet having an adhesive face and at least an adhesive layer comprising an adhesive and a liquid component compatible with the adhesive, and the traveling speed of the adhesive sheet on the runway being 0.064 mm/second to 2000 mm/second, the adhesive being an acrylic adhesive, the liquid component being an organic liquid component comprising at least one of fatty acid alkyl esters and glycerol fatty acid esters, and a mixing ratio of the adhesive and the liquid component in the adhesive layer being 1:0.25-1:1.8 in a weight ratio,
• providing a drug liquid application part that applies a given amount of a drug liquid, the drug liquid being a nicotine and/or a nicotine solution, to the adhesive face of the traveling adhesive sheet,
• wherein the combination of the drug liquid, an adhesive and the liquid component is determined so as:
• to impregnate the adhesive layer with the drug liquid, and
• to achieve a contact angle of the drug liquid with the adhesive face of 20 degrees-60 degrees,
• wherein the drug liquid application part discharges a given amount of a drug liquid on the adhesive face from a delivery head arranged in close proximity to the adhesive face,
• providing a traveling section for impregnation positioned along the runway after the drug liquid application part, the traveling section enabling the adhesive sheet to run for a period necessary for the applied drug liquid to soak into the adhesive layer,
• wherein the length of the traveling section for impregnation is 70 mm to 30000 mm, and the length is determined based on the traveling speed of the adhesive sheet so the adhesive sheet runs along the traveling section for impregnation for 15 seconds to 1100 seconds, which is the time necessary for penetration of all the drug liquid applied, and
• wherein the runway comprises a roll in contact with the back face of the adhesive sheet, the roll having a horizontal rotation shaft, the runway is arranged in such a manner that the adhesive face of the adhesive sheet rotates from a downward position to an upward position for 180 degrees along the roll, and the delivery head is positioned within the range of −90 degrees to +90 degrees about the middle point between the lowermost point and the uppermost point of the roll.