Inhibitors of bacterial biofilms and related methods
AssigneeSequoia Sciences, Inc.
InventorsGary R. Eldridge, Ronald Neil Buckle, Michael Ellis, Zhongping Huang, John Edward Reilly
Life of this patent
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Abstract
Certain multi-cyclic compounds and compositions thereof are useful for reducing or inhibiting the growth of bacterial biofilms and for controlling bacterial biofilm infections. Such compounds and compositions are also useful in methods for reducing or inhibiting the growth of biofilms and for controlling bacterial biofilm infections involving biofilms.
Claims62
A compound corresponding to the following chemical structure:
- wherein R1 is selected from the group consisting of hydrogen, methyl, halide, lower haloalkyl, nitrile, lower alkyl nitrile, lower alkyl, substituted lower alkyl, lower alkenyl, substituted lower alkenyl, lower alkynyl, substituted lower alkynyl, lower cycloalkyl, lower cycloalkenyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl;
- wherein R2 is selected from the group consisting of carboxyl, amide, hydroxyamide, methylamide, —CH2N(CH3)2, —CH2NR6R7,
- wherein R3 is selected from the group consisting of hydrogen and methyl;
- wherein one of R4 and R5 is hydrogen and the other is methyl;
- wherein R6 and R7 are independently selected from the group consisting of hydrogen, methyl, ethyl, propyl, isopropyl, and butyl;
- wherein R8 is selected from the group consisting of hydroxyl, amino, —N(CH3)2, and —NHCH3;
- and wherein R9 is selected from the group consisting of hydrogen, halide, lower alkyl, lower alkenyl, lower alkynyl, morpholinyl, piperazinyl, lower alkyl piperazinyl, heterocycloalkyl, lower cycloalkyl, lower cycloalkenyl;
- and lower alkyl, lower alkenyl, and lower alkynyl optionally substituted with moieties selected from the group consisting of hydroxyl, amino, lower aminoalkyl, halide, lower alkoxy, lower alkoxyalkyl, lower alkoxycarbonyl, lower alkylcarbonylamino, amide, hydroxyamide, —CONHCH3, —NHCONH2, —SO2NH2, —SO2CH3, —NHCOCH3, —NHCSNH2, and —NHSO2CH3;
- and salts thereof.
A method for reducing the formation or growth of a biofilm comprising contacting the biofilm with an effective amount of a compound or composition comprising a compound corresponding to the following chemical structure:
- wherein R1 is selected from the group consisting of hydrogen, methyl, halide, lower haloalkyl, nitrile, lower alkyl nitrile, lower alkyl, substituted lower alkyl, lower alkenyl, substituted lower alkenyl, lower alkynyl, substituted lower alkynyl, lower cycloalkyl, lower cycloalkenyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl;
- wherein R2 is selected from the group consisting of carboxyl, amide, hydroxyamide, methylamide, —CH2N(CH3)2, —CH2NR6R7,
- wherein R3 is selected from the group consisting of hydrogen and methyl;
- wherein one of R4 and R5 is hydrogen and the other is methyl;
- wherein R6 and R7 are independently selected from the group consisting of hydrogen, methyl, ethyl, propyl, isopropyl, and butyl;
- wherein R8 is selected from the group consisting of hydroxyl, amino, —N(CH3)2, and —NHCH3;
- and wherein R9 is selected from the group consisting of hydrogen, halide, lower alkyl, lower alkenyl, lower alkynyl, morpholinyl, piperazinyl, lower alkyl piperazinyl, heterocycloalkyl, lower cycloalkyl, lower cycloalkenyl;
- and lower alkyl, lower alkenyl, and lower alkynyl substituted with moieties selected from the group consisting of hydroxyl, amino, lower aminoalkyl, halide, lower alkoxy, lower alkoxyalkyl, lower alkoxycarbonyl, lower alkylcarbonylamino, carboxyl, amide, hydroxyamide, —CONHCH3, —NHCONH2, —SO2NH2, —SO2CH3, —NHCOCH3, —NHCSNH2, and —NHSO2CH3;
- and salts thereof.
Dependencies are inferred from the claim text.