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US 8,323,657 B2Granted
Antigenic polypeptide usable as therapeutic agent for malignant neoplasm
AssigneeNational University Corporation Hokkaido University
InventorTakashi Nishimura
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Abstract
This invention provides a new tumor antigen having an epitope that induces a Th1 cell (a CD4-positive T cell specific to MAGE-A4), and a method ot application thereof.
Claims9
A polypeptide consisting of an amino acid sequence of SEQ ID No:
- 2, wherein said polypeptide has cytokine-producing activity in a Th cell specific to MAGE-A4.
A polypeptide consisting of an amino acid sequence of SEQ ID No:
- 2, wherein one to fifty of any amino acids are added to the N terminus and/or the C terminus of an amino acid sequence of SEQ ID No:
- 2 and the overall length of the polypeptide is from 20 to 120 amino acids and wherein said polypeptide has cytokine-producing activity in a Th cell specific to MAGE-A4.
A polypeptide consisting of an amino acid sequence of SEQ ID No:
- 2, wherein one to five amino acids from the N terminus and/or the C terminus of an amino acid sequence of SEQ ID No:
- 2 are deleted and the overall length of the polypeptide is no longer than 20 amino acids and wherein said polypeptide has cytokine-producing activity in a Th cell specific to MAGE-A4.
Dependencies are inferred from the claim text.