Ultrasmall superparamagnetic iron oxide nanoparticles and uses thereof
AssigneeUniversity of Houston System
InventorMalavosklish Bikram
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Abstract
The present invention provides biomimetic contrast agents, dual functional contrast agents effective for therapeutic gene delivery and magnetic nanoparticles which comprise functionalized iron oxide nanoparticle cores, one of an inert gold layer, a layer of inert metal seeds or a silica layer and, optionally, one or both of an outer gold-silver nanoshell or a targeting ligand attached to the inert gold layer or the gold-silver nanoshell. Also provided are methods of in vivo magnetic resonance imaging, of treating primary or metastatic cancers or of ablating atherosclerotic plaque using the contrast agents and magnetic particles. In addition, kits comprising the biomimetic contrast agents, dual contrast agents and magnetic nanoparticles.
Claims17
A magnetic nanoparticle, comprising:
- a functionalized inner core comprising iron oxide, wherein said inner core is functionalized with a silica layer;
- an inert metal seeding the functionalized core;
- and
- an outer inert metal alloy nanoshell.
A magnetic nanoparticle, comprising:
- an amine-functionalized metal-doped iron(III) oxide core;
- a layer of gold seeding on the amine-functionalized metal-doped iron oxide core;
- an outer gold-silver alloy nanoshell;
- and a targeting ligand attached to the nanoshell via a linker.
A magnetic nanoparticle, comprising:
- an iron(III) oxide/iron(II) core;
- a layer of silica around the core;
- an outer gold-silver alloy nanoshell;
- and
- a targeting ligand attached to the nanoshell via a linker.
Dependencies are inferred from the claim text.