Method and system for patient-specific modeling of blood flow

A method for determining patient-specific cardiovascular information using at least one computer system, the method comprising:

• inputting into the at least one computer system patient-specific data regarding a geometry of an anatomical structure of the patient, the anatomical structure including at least a portion of a plurality of coronary arteries emanating from an aorta;
• creating, using the at least one computer system, a three-dimensional model representing a first portion of the anatomical structure based on the patient-specific data, the first portion of the anatomical structure including at least the portion of the plurality of coronary arteries, the three-dimensional model representing at least one fluid flow inlet and at least one fluid flow outlet;
• creating, using the at least one computer system, at least one boundary condition model representing fluid flow through at least one of the at least one inlet or the at least one outlet, based at least in part on a mass or a volume of myocardial tissue;
• and
• determining, using the at least one computer system, a fractional flow reserve within the first portion of the anatomical structure based on the three-dimensional model and the at least one boundary condition model.

A system for determining cardiovascular information for a patient, the system comprising:

• at least one computer system configured to:
• receive patient-specific imaging data regarding a geometry of an anatomical structure of the patient, the anatomical structure including at least a portion of a plurality of coronary arteries emanating from an aorta;
• create a three-dimensional model representing a first portion of the anatomical structure based on the patient-specific imaging data, the first portion of the anatomical structure including at least the portion of the plurality of coronary arteries, the three-dimensional model representing at least one fluid flow inlet and at least one fluid flow outlet;
• create at least one boundary condition model representing fluid flow through at least one of the at least one inlet or the at least one outlet, based at least in part on a mass or a volume of myocardial tissue;
• and
• determine fractional flow reserve at a plurality of locations within the first portion of the anatomical structure based on the three-dimensional model and the at least one boundary condition model;
• wherein the at least one boundary condition model has less than three dimensions;
• and
• wherein the fractional flow reserve indicates a ratio between a pressure at a first location in the plurality of coronary arteries and a second location upstream from the first location.

A method for determining patient-specific cardiovascular information using at least one computer system, the method comprising:

• inputting into the at least one computer system patient-specific imaging data regarding a geometry of an anatomical structure of the patient, the anatomical structure including at least a portion of a plurality of coronary arteries emanating from an aorta;
• creating, using the at least one computer system, a three-dimensional model representing a first portion of the anatomical structure based on the patient-specific imaging data, the first portion of the anatomical structure including at least the portion of the plurality of coronary arteries, the three-dimensional model representing at least one fluid flow inlet and at least one fluid flow outlet;
• creating, using the at least one computer system, at least one boundary condition model representing fluid flow through at least one of the at least one inlet or the at least one outlet, based at least in part on a mass or a volume of myocardial tissue;
• and
• determining, using the at least one computer system, fractional flow reserve at a plurality of locations within the first portion of the anatomical structure based on the three-dimensional model and the at least one boundary condition model;
• wherein the at least one boundary condition model has less than three dimensions;
• and
• wherein the fractional flow reserve indicates a ratio between a pressure at a first location in the plurality of coronary arteries and a second location upstream from the first location.