Controlled release antimicrobial compositions and methods for the treatment of otic disorders
AssigneesOtonomy, Inc., The Regents of the University of California
InventorsJay Lichter, Carl Lebel, Fabrice Piu, Qiang Ye, Luis A. Dellamary, Andrew M. Trammel, Jeffrey P. Harris
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Abstract
Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
Claims11
A method of treating an otic infection or inflammation comprising intratympanically administering to an individual in need thereof a composition comprising a therapeutically effective amount of a multiparticulate antimicrobial agent, the composition further comprising
- (i) a-copolymer of polyoxyethylene and polyoxypropylene in an amount sufficient to provide a non-gelation viscosity that allows injection with a 18-31 gauge needle through the tympanic membrane into the ear, a gelation viscosity between about 15,000 cP and about 1,000,000 cP and a gelation temperature of between about room temperature and about body temperature;
- and
- (ii) having an osmolarity of less than 1000 mOsm/L;
- wherein the composition is a liquid at about room temperature and is administered at or about room temperature, and provides a sustained release of the antimicrobial agent in the ear for a period of at least 5 days after a single intratympanic administration.
Dependencies are inferred from the claim text.