Method and device for desorption ionization by liquid jet
AssigneeSemmelweis Egyetem
InventorZoltán Takáts
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Abstract
The invention relates to method and apparatus for production of gaseous ions from components of a condensed phase sample and analysis thereof, wherein one or more liquid jet(s) is/are directed to the surface of the sample to be investigated, where the impact of the liquid jet on the sample surface produces droplets carrying sample particles which are turned into gaseous ions via the evaporation of liquid or, if desired, by a subsequent ionization after the evaporation and the obtained sample particles are analyzed by a known method.
Claims37
A method of analyzing a sample which is a condensed phase material, the method comprising:
- applying a liquid jet to a surface of the sample, wherein said liquid jet comprises a stream of liquid with sufficient pressure to penetrate the surface of said sample without the need for solvent action, thereby producing liquid droplets containing ions or sample particles convertible into ions;
- obtaining gaseous ions by evaporating or allowing to be evaporated liquid of the droplets;
- and
- analyzing the obtained gaseous ions with an analyzer unit.
An apparatus for converting components of a condensed phase sample into gaseous ions and analysis thereof, comprising:
- a sample collector unit;
- an analyzer unit configured to receive and analyze gaseous ions from the sample collector unit;
- and
- a desorption unit has having a target location for placement of a sample and a nozzle directed to said target location, said nozzle configured to provide a liquid jet comprising a stream of liquid with sufficient pressure to penetrate a surface of a condensed phase sample without the need for solvent action, thereby producing liquid droplets containing ions or sample particles convertible into ions.
An apparatus for converting components of a condensed phase sample into gaseous ions and analysis thereof, comprising:
- a sample collector comprising a tube connected to an analyzer unit;
- and
- a desorption unit has having a target location for placement of a sample and a nozzle directed to said target location, said nozzle configured to provide a liquid jet comprising a stream of liquid with sufficient pressure to penetrate a surface of a condensed phase sample without the need for solvent action, thereby producing liquid droplets containing ions or sample particles convertible into ions,
- wherein said desorption unit and said tube are fastened to each other by a holder.
Dependencies are inferred from the claim text.