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US 8,313,896 B2Granted
Oncolytic herpes simplex virus immunotherapy in the treatment of brain cancer
AssigneeThe General Hospital Corporation
InventorsRobert L. Martuza, Samuel Rabkin, William Curry, Christopher Farrell, Cecile Zaupa
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Abstract
Method of stimulating an immune response (e.g., to treat cancer) include administering to a subject a composition including dendritic cells incubated with (i) oHSV-infected tumor cells or a composition derived therefrom, or (ii) tumor cells plus oHSV, as well as methods of preparing such compositions, are described.
Claims4
A method of treating a subject for a brain tumor comprising:
- administering to the subject a composition comprising mature dendritic cells produced by incubating a population of immature dendritic cells generated from a sample obtained from the subject or a closely matched donor, with:
- (i) a brain tumor cell of the subject, infected with an effective amount of oncolytic herpes simplex virus (oHSV) G207 or G47Δ;
- (ii) a composition derived from a brain tumor cell of the subject infected with an effective amount of oHSV G207 or G47Δ, wherein the composition is selected from the group consisting of supernatant, conditioned medium, eluate, and lysate;
- (iii) A brain tumor cell of the subject and an effective amount of oHSV G207 or G47Δ;
- or
- (iv) a composition derived from a brain tumor cell of the subject and an effective amount of oHSV G207 or G47Δ, wherein the composition is selected from the group consisting of supernatant, conditioned medium, eluate, and lysate;
- to thereby produce mature dendritic cells;
- to thereby treat the subject for the brain tumor.
5 more elements
Dependencies are inferred from the claim text.