Back to results
US 8,309,355 B2Granted
Methods of treating Parkinson's disease using viral vectors
AssigneesGenzyme Corporation, The Regents of the University of California
InventorsKrys Bankiewicz, Janet Cunningham
Life of this patent
Estimating the term…
Abstract
Methods of delivering viral vectors, particularly recombinant AAV virions, to the central nervous system (CNS) are provided for the treatment of CNS disorders, particularly those disorders which involve the neurotransmitter dopamine. The methods entail providing rAAV virions that comprise a transgene encoding aromatic amino acid decarboxylase (AADC) and administering the virions to the brain of a mammal using a non-manual pump.
Claims12
A method of increasing dopamine levels in a mammal, said method comprising:
- (a) providing a composition comprising at least 2.5×109 recombinant adeno-associated virus (rAAV) virions, wherein said rAAV virions comprise a transgene encoding aromatic amino acid decarboxylase (AADC);
- and
- (b) administering said composition directly to the brain of said mammal using a non-manual pump, to increase dopamine levels, wherein said composition is administered such that distribution of said rAAV virions is over an area greater than 5 mm2.
Dependencies are inferred from the claim text.