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US 8,309,347 B2Granted
Cell expansion system and methods of use
AssigneeTerumo BCT, Inc.
InventorGlen Delbert Antwiler
Life of this patent
Estimating the term…
Abstract
Cell expansion systems and methods of use are provided. The cell expansion systems generally include a hollow fiber cell growth chamber, and first and second circulation loops (intracapillary loops and extracapillary loops) associated with the interior of the hollow fibers and exterior of the hollow fibers, respectively. Detachable flow circuits and methods of expanding cells are also provided.
Claims15
A cell expansion system comprising:
- a) a first fluid circulation path comprising
- i) a first fluid flow path having at least opposing ends, a first opposing end of said first fluid flow path fluidly associated with a first inlet port of a hollow fiber membrane containing cell growth chamber and a second opposing end of said first fluid flow path fluidly associated with a first outlet port of said cell growth chamber, wherein said first fluid flow path is fluidly associated with an intracapillary portion of said hollow fiber membrane, and
- ii) a first fluid controller operably associated with said first fluid flow path;
- b) a second fluid circulation path comprising
- i) a second fluid flow path having at least opposing ends, a first opposing end of said second fluid flow path fluidly associated with a second inlet port of said cell growth chamber and a second opposing end of the second fluid flow path fluidly associated with a second outlet port of said cell growth chamber, wherein the second fluid flow path is fluidly associated with an extracapillary portion of said hollow fiber membrane;
- and
- ii) a second fluid controller operably associated with said second fluid flow path;
- c) a first fluid inlet path fluidly associated with said first fluid circulation path to allow fluid into said first fluid circulation path;
- d) a first fluid outlet path fluidly associated with at least one of said first or second fluid circulation paths;
- e) at least one fluid connector path having at least opposing ends, a first opposing end of said fluid connector path fluidly associated with said first fluid circulation path and a second opposing end of said fluid connector path fluidly associated with said second fluid circulation path, wherein the at least one fluid connector path comprises a third fluid controller;
- and
- f) a second fluid connector flow path having opposing ends, one end of said second fluid connector flow path fluidly associated with said first fluid flow path and a second end of said second fluid connector flow path fluidly associated with said second fluid flow path, wherein the second fluid connector flow path comprises a fourth fluid controller.
9 more elements
Dependencies are inferred from the claim text.