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US 8,309,121 B2Granted
Dermatological compositions comprising avermectin nanocapsules
AssigneeGalderma S.A.
InventorsLara Baudonnet, Claire Mallard
Life of this patent
Estimating the term…
Abstract
Compositions and nanoemulsions containing lipid nanocapsules dispersed in a hydrophilic phase, such nanocapsules including at least one avermectin compound, are useful for the treatment of dermatological pathologies, e.g., rosacea.
Claims21
A composition comprising lipid nanocapsules, said lipid nanocapsules comprising:
- (a) an oily inner phase consisting of diisopropyl adipate and ivermectin solubilized in said diisopropyl adipate;
- and
- (b) a surfactant comprising soybean and/or egg lecithin(s) having a hydrogenated phosphatidylcholine content of greater than 70% by weight, said surfactant being lipophilic, solid at room temperature and coating said oily inner phase;
- said lipid nanocapsules being dispersed in a continuous hydrophilic phase;
- said composition being devoid of any surfactant(s) other than said lecithin(s);
- said composition being devoid of any organic solvent(s) other than said diisopropyl adipate;
- said composition being devoid of propenetrating agents;
- said composition being physically stable at 4° C., ambient temperature and 40° C., for a period of two months;
- said ivermectin being chemically stable in said composition at 4° C., ambient temperature and 40° C., for a period of three months.
6 more elements
A composition comprising lipid nanocapsules, said lipid nanocapsules comprising:
- (a) an oily inner phase consisting of diisopropyl adipate and ivermectin solubilized in said diisopropyl adipate;
- and
- (b) a surfactant comprising soybean and/or egg lecithin(s) having a hydrogenated phosphatidylcholine content of greater than 70% by weight, said surfactant being lipophilic, solid at room temperature and coating said oily inner phase;
- said lipid nanocapsules being dispersed in a continuous hydrophilic phase;
- and
- said composition further comprising a gelling agent which is a cellulose derivative selected from the group consisting of methylcellulose, ethylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose, carboxymethylcellulose, hydroxymethylcellulose and hydroxypropylcellulose, and mixtures thereof;
- said composition being devoid of any surfactant(s) other than said lecithin(s);
- said composition being devoid of any organic solvent(s) other than said diisopropyl adipate;
- said composition being devoid of propenetrating agents;
- said composition being physically stable at 4° C., ambient temperature and 40° C., for a period of nine months;
- said ivermectin being chemically stable in said composition at 4° C., ambient temperature and 40° C., for a period of three months.
8 more elements
A composition comprising lipid nanocapsules, said lipid nanocapsules comprising:
- (a) an oily inner phase consisting of diisopropyl adipate and ivermectin solubilized in said diisopropyl adipate;
- and
- (b) a surfactant comprising soybean and/or egg lecithin(s) having a hydrogenated phosphatidylcholine content of greater than 70% by weight, said surfactant being lipophilic, solid at room temperature and coating said oily inner phase;
- said lipid nanocapsules being dispersed in a continuous hydrophilic phase;
- said composition being devoid of any surfactant(s) other than said lecithin(s);
- said composition being devoid of any organic solvent(s) other than said diisopropyl adipate;
- said composition being devoid of propenetrating agents;
- said composition being physically and chemically stable at 4° C., ambient temperature and 40° C., for a period of at least two months.
5 more elements
A composition comprising lipid nanocapsules, said lipid nanocapsules comprising:
- (a) an oily inner phase consisting of diisopropyl adipate and ivermectin solubilized in said diisopropyl adipate;
- and
- (b) a surfactant comprising soybean and/or egg lecithin(s) having a hydrogenated phosphatidylcholine content of greater than 70% by weight, said surfactant being lipophilic, solid at room temperature and coating said oily inner phase;
- said lipid nanocapsules being dispersed in a continuous hydrophilic phase;
- and
- said composition further comprising a gelling agent which is a cellulose derivative selected from the group consisting of methylcellulose, ethylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose, carboxymethylcellulose, hydroxymethylcellulose and hydroxypropylcellulose, and mixtures thereof;
- said composition being devoid of any surfactant(s) other than said lecithin(s);
- said composition being devoid of any organic solvent(s) other than said diisopropyl adipate;
- said composition being devoid of propenetratinq agents;
- said composition being physically and chemically stable at 4° C., ambient temperature and 40° C., for a period of at least three months.
7 more elements
Dependencies are inferred from the claim text.