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AssigneeSemprus Biosciences Corp.
InventorsZheng Zhang, Chad Huval, William Shannan O'Shaughnessey, Michael Hencke, Trevor Squier, Jun Li, Michael Bouchard, Christopher R. Loose
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Substrates, optionally coated with an undercoating, having grafted thereto one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted to a variety of functionalized substrate materials, particularly polymeric substrates and/or polymeric undercoatings immobilized on a substrate. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted to a functionalized substrate, or optionally from an undercoating on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.
A composition comprising a functionalized substrate in the form of a medical device containing lumens, cavities, porous structures, or combinations thereof, the functionalized substrate having a polymeric undercoat immobilized thereon and a non-fouling polymeric topcoat copolymer covalently bound to the polymeric undercoat, the polymeric undercoat being between the functionalized substrate and the non-fouling polymeric topcoat copolymer, wherein more than 35 mole % of the polymerized monomers comprised by the non-fouling polymeric topcoat copolymer are polyether moieties or phosphorylcholine, sulfobetaine or carboxybetaine zwitterionic moieties, the polymeric undercoat and the non-fouling polymeric topcoat copolymer comprising complementary reactive functional groups wherein the non-fouling polymeric topcoat copolymer is covalently bound to the polymeric undercoat via covalent bonds formed by the complementary reactive functional groups.
A method of making a composition in the form of a medical device containing lumens, cavities, porous structures, or combinations thereof, the method comprising immobilizing a polymeric undercoat having reactive functional groups on the medical device and grafting a non-fouling polymeric topcoat copolymer to the immobilized polymeric undercoat, the non-fouling polymeric topcoat copolymer having reactive functional groups, the undercoat reactive functional groups and the non-fouling polymeric topcoat copolymer reactive functional groups being complementary wherein the non-fouling polymeric topcoat copolymer is covalently bound to the polymeric undercoat via covalent bond formation between the complementary reactive functional groups and more than 35 mole % of the polymerized monomers comprised by the non-fouling polymeric topcoat copolymer are polyether moieties or phosphorylcholine, sulfobetaine or carboxybetaine zwitterionic moieties.
Dependencies are inferred from the claim text.