Method for data reduction and calibration of an OCT-based physiological monitor

A method for calibrating an optical coherence tomography (OCT) sensor by correlating OCT measurements with blood analyte measurements, comprising:

• receiving blood analyte measurements from a subject over a period of time;
• obtaining OCT measurements from biological tissue of the subject using an OCT sensor such that at least one OCT measurement is associated with each blood analyte measurement, each of the OCT measurements capable of being represented as a plot of intensity against depth of the biological tissue;
• identifying at least one discontinuity in data associated with an obtained OCT measurement;
• selecting, based on the at least one discontinuity, a portion of each of the OCT measurements correlating with the associated blood analyte measurements, the portion including a selected depth;
• and
• determining, using a processor, a calibration relationship for the OCT sensor using the selected portions of the OCT measurements and the associated blood analyte measurements.

A method for calibrating an optical coherence tomography (OCT) sensor by correlating OCT measurements with blood analyte measurements, comprising:

• receiving blood analyte measurements from a subject over a period of time;
• obtaining OCT measurements from biological tissue of the subject using an OCT sensor such that at least one OCT measurement is associated with each blood analyte measurement, each of the OCT measurements capable of being represented as a plot of intensity against depth of the biological tissue;
• generating a Pearson plot to indicate correlations between a plurality of OCT measurements at a plurality of portions and depths of the OCT measurements;
• selecting, based on the Pearson plot, a portion of the OCT measurements correlating with the associated blood analyte measurements, the portion including a selected depth;
• and
• determining, using a processor, a calibration relationship for the OCT sensor using the selected portions of the OCT measurements and the associated blood analyte measurements.

A physiological monitoring system for determining a blood analyte level using an optical coherence tomography (OCT) sensor comprising:

• a non-invasive OCT sensor configured to:
• scan an area of biological tissue and a depth dimension during a period of time;
• and
• generate OCT measurements based on the scanning;
• and
• a physiological monitor comprising at least one processor, the physiological monitor configured to:
• receive the OCT measurements;
• compute intensity differences between at least two of the OCT measurements at corresponding depths to generate an intensity difference plot;
• determine a first depth from the intensity difference plot comprising a region having a large change in intensity;
• select one or more portions of the OCT measurements corresponding to the first depth;
• and
• determine an estimated blood analyte level in the biological tissue based on a comparison of the one or more selected portions of the OCT measurements corresponding to the first depth to one or more OCT calibration curves.

A physiological monitoring system for determining a blood analyte level using an optical coherence tomography (OCT) sensor comprising:

• a non-invasive OCT sensor configured to:
• scan an area of biological tissue and a depth dimension during a period of time;
• and
• generate OCT measurements based on the scanning;
• and
• a physiological monitor comprising at least one processor, the physiological monitor configured to:
• identify at least one discontinuity in data associated with an obtained OCT measurement;
• determine a first depth based on using the at least one discontinuity;
• select one or more portions of the OCT measurements corresponding to the first depth;
• and
• determine an estimated blood analyte level in the biological tissue based on a comparison of the one or more selected portions of the OCT measurements corresponding to the first depth to one or more OCT calibration curves.

A physiological monitoring system for determining a blood analyte level using an optical coherence tomography (OCT) sensor comprising:

• a non-invasive OCT sensor configured to:
• scan an area of biological tissue and a depth dimension during a period of time;
• and
• generate OCT measurements based on the scanning;
• and
• a physiological monitor comprising at least one processor, the physiological monitor configured to:
• generate a Pearson plot to indicate correlations between a plurality of OCT measurements at a plurality of portions and depths of the OCT measurements;
• determine a first depth based on using the Pearson plot;
• select one or more portions of the OCT measurements corresponding to the first depth;
• and
• determine an estimated blood analyte level in the biological tissue based on a comparison of the one or more selected portions of the OCT measurements corresponding to the first depth to one or more OCT calibration curves.