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US 8,301,257 B2Granted
Method for suppressing and reversing epileptogenesis
AssigneeWisconsin Alumni Research Foundation
InventorsDavid Ambrose Hsu, Murielle Aline Hsu, John Matthew Beggs
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Abstract
A method for identifying, suppressing, and reversing epileptogenesis, which is considered to be a learned response due to brain plasticity. The method includes identifying three epileptogenic conditions, neuronal hyperexcitability, spatial overconnectivity, and temporal overconnectivity. A treatment that accounts for each of these conditions is then be administered to the subject to reverse, or “unlearn,” epilepsy.
Claims11
A method for identifying and reducing a subject's risk of epilepsy, the method comprising:
- a) acquiring neural activity data from the subject;
- b) analyzing the acquired neural activity data by:
- b) i) calculating, from the acquired neural activity data, a parameter indicative of neuronal hyperexcitability due to imbalances between excitatory and inhibitory influences;
- b) ii) calculating, from the acquired neural activity data, a parameter indicative of spatial overconnectivity that leads to abnormally wide spreads of neuronal activity;
- and
- b) iii) calculating, from the acquired neural activity data, a parameter indicative of temporal overconnectivity that leads to abnormally persistent neuronal activity, wherein the parameter indicative of temporal overconnectivity accounts for non-Markovian effects;
- c) determining epileptic patterns in the subject based on the parameters calculated in step b);
- and
- d) administering a treatment to the subject configured to reverse the epileptic patterns determined in step c).
6 more elements
Dependencies are inferred from the claim text.