Ion source
AssigneeShimadzu Research Laboratory (Shanghai) Co. Ltd.
InventorsLi Ding, Wenjian Sun
Life of this patent
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Abstract
This invention relates to a desorption/ionization source operated under ambient conditions for direct analysis of solid or liquid samples on a surface. The source comprises of a laser desorption system and a UV/electrospray combined ionization system. The source is suitable for simultaneously ionizing samples with different polarity in a complex mixture. At the same time, the compact design of the source with multiple channels can maintain the level of local concentration of the analyte ions inside the source for higher efficiency of sample ionization and introduction.
Claims23
An atmospheric pressure desorption/ionization source comprising:
- a laser and related optical system for desorbing or vaporizing analytes from a solid or liquid sample surface;
- a UV lamp near a desorption/vaporization region for photoionizing at least a portion of the desorbed/vaporized analytes;
- a spray source for introducing a dopant to an area above the desorption/vaporization region in order to assist the photoionization process by directly or indirectly ionizing the desorbed/vaporized analytes;
- and
- an ion inlet connecting the atmospheric pressure desorption/ionization source to a mass spectrometer.
A method for direct analysis of samples from a surface in atmospheric pressure, comprising:
- desorbing/vaporizing analytes from a sample surface using a laser;
- forming ions by photoionizing the desorbed/vaporized analytes using a UV lamp;
- and
- introducing a dopant with a spray source to a region above a desorption/vaporization area in order to assist the photoionization process by directly or indirectly ionizing the desorbed/vaporized analytes.
Dependencies are inferred from the claim text.