Hemostatic device
AssigneeEthicon, Inc.
InventorsRobert W. Van Holten, Jagdishchandra C. Patel, Stephen C. Yeadon
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Abstract
A hemostatic device comprising (i) a carrier comprising at least one component selected from the group consisting of hydroxypropyl methylcellulose phthalate, hydroxypropyl methylcellulose acetate succinate, cellulose acetate phthalate; polyvinylacetate phthalate, cellulose acetate phthalate, acetaldehyde dimethylcellulose acetate, polymethacrylate-based polymers, and derivatives, salts, copolymers or combinations thereof; and (ii) thrombin.
Claims42
A hemostatic device consisting of a nonwoven, woven or knitted fabric substrate, and a hemostatic coating on one or both faces thereof comprising:
- a carrier selected from the group consisting of hydroxypropyl methylcellulose phthalate, hydroxypropyl methylcellulose acetate succinate, polyvinylacetate phthalate, cellulose acetate phthalate, acetaldehyde dimethylcellulose acetate, polymethacrylate-based polymers, and derivatives, salts, copolymers and combinations thereof;
- and
- at least two reactive components that are capable of polymerizing only in situ, which are fibrinogen and thrombin, where the fibrinogen is adjacent to a surface of the coating but not adjacent to the substrate, and the thrombin is adjacent to the substrate but not adjacent to the surface of the coating.
A hemostatic device consisting of a carrier sheet having first and second faces, selected from the group consisting of hydroxypropyl methylcellulose phthalate, hydroxypropyl methylcellulose acetate succinate, polyvinylacetate phthalate, cellulose acetate phthalate, acetaldehyde dimethylcellulose acetate, polymethacrylate-based polymers, and derivatives, salts, copolymers and combinations thereof, and at least two reactive components that are capable of polymerizing only in situ, which are fibrinogen and thrombin;
- and optionally a supporting substrate for said carrier sheet, where the fibrinogen is on the first face but not on the second face, and the thrombin is on the second face but not on the first face.
A hemostatic device consisting of a nonwoven, woven or knitted fabric substrate, and a hemostatic coating on one or both faces thereof comprising:
- a carrier selected from the group consisting of hydroxypropyl methylcellulose phthalate, hydroxypropyl methylcellulose acetate succinate, polyvinylacetate phthalate, cellulose acetate phthalate, acetaldehyde dimethylcellulose acetate, polymethacrylate-based polymers, and derivatives, salts, copolymers and combinations thereof;
- and at least two reactive components that are capable of polymerizing in situ, which are fibrinogen and thrombin, where the thrombin is adjacent to a surface of the coating but not adjacent to the substrate, and the fibrinogen is adjacent to the substrate but not adjacent to the surface of the coating.
A hemostatic device consisting of a nonwoven, woven or knitted fabric substrate, and a hemostatic coating on one or both faces thereof comprising:
- a carrier selected from the group consisting of hydroxypropyl methylcellulose phthalate, hydroxypropyl methylcellulose acetate succinate, polyvinylacetate phthalate, cellulose acetate phthalate, acetaldehyde dimethylcellulose acetate, polymethacrylate-based polymers, and derivatives, salts, copolymers and combinations thereof;
- and at least two reactive components that are capable of polymerizing in situ, which are fibrinogen and thrombin, where the fibrinogen is dispersed within the carrier coating but not adjacent to a surface of the carrier coating, and the thrombin is adjacent to the surface of the coating but not dispersed within the carrier coating.
A hemostatic device consisting of a nonwoven, woven or knitted fabric substrate, and a hemostatic coating on one or both faces thereof comprising:
- a carrier selected from the group consisting of hydroxypropyl methylcellulose phthalate, hydroxypropyl methylcellulose acetate succinate, polyvinylacetate phthalate, cellulose acetate phthalate, acetaldehyde dimethylcellulose acetate, polymethacrylate-based polymers, and derivatives, salts, copolymers and combinations thereof;
- and at least two reactive components that are capable of polymerizing in situ, which are fibrinogen and thrombin, where the thrombin is dispersed within the carrier coating but not adjacent to a surface of the carrier coating, and the fibrinogen is adjacent to the surface of the coating but not dispersed within the carrier coating.
Dependencies are inferred from the claim text.