(3-hydroxy-4-amino-butan-2-yl) -3- (2-thiazol-2-yl-pyrrolidine-1-carbonyl) benzamide derivatives and related compounds as beta-secretase inhibitors for treating

A compound having the formula:

• wherein
• A1 is a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• A2 is a substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene;
• X is —CH2—, —O—, —N(R8)—, or —S(O)w—;
• or where X is —CH— or —N—, and is the attachment point for R6 or R7;
• L1 and L5 are independently a bond, —N(R17)—, —S(O)q—, or substituted or unsubstituted alkylene;
• L4 is a bond, —C(O)—, —N(R17)—, —S(O)q—, or substituted or unsubstituted alkylene;
• R2 and R3 are independently hydrogen, —S(O)2R11, —C(O)R12, —N(R8)R9, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkyl-alkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted heterocycloalkyl-alkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heteroaralkyl;
• R4 and R5 are independently hydrogen, halogen, —OH, —NO2, —N(R8)R9, —OR10, —S(O)nR11, —C(O)R12, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkyl-alkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted heterocycloalkyl-alkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heteroaralkyl;
• R6 and R7 are independently hydrogen, halogen, —OH, —NO2, —N(R8)R9, —OR10, —S(O)nR11, —C(O)R12, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkyl-alkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted heterocycloalkyl-alkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heteroaralkyl;
• R8 is independently hydrogen, —C(O)R13, —S(O)2R14, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkyl-alkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted heterocycloalkyl-alkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heteroaralkyl;
• R9 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkyl-alkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted heterocycloalkyl-alkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heteroaralkyl;
• R10 is independently —C(O)R13, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkyl-alkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted heterocycloalkyl-alkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heteroaralkyl;
• R11 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkyl-alkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted heterocycloalkyl-alkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heteroaralkyl, wherein if n is 2, then R11 can also be —NR15R16, and wherein if n is 1 or 2, then R11 is not hydrogen;
• R12 and R13 are each independently hydrogen, —N(R18)R19, —OR19, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkyl-alkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted heterocycloalkyl-alkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heteroaralkyl;
• R14 is independently hydrogen, —N(R18)R19, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted heterocycloalkyl-alkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heteroaralkyl;
• R15, R16, R17, R18, and R19 are each independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkyl-alkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted heterocycloalkyl-alkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heteroaralkyl;
• and
• m, n, q, and w are each independently 0, 1, or 2;
• or a pharmaceutically acceptable salt or solvate thereof.