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US 8,299,259 B2Granted
4-(azacycloalkyl)benzene-1,3-diol compounds as tyrosinase inhibitors, process for the preparation thereof and use thereof in human medicine and in cosmetics
AssigneeGalderma Research & Development
InventorsJean-Guy Boiteau, Karine Bouquet, Sandrine Talano, Corinne Millois Barbuis
Life of this patent
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Abstract
4-(azacycloalkyl)benzene-1,3-diol compounds are described corresponding to general formula (I) below: Also described, are compositions including the same, processes for preparation thereof and uses thereof in pharmaceutical or cosmetic compositions to treat pigmentary disorders.
Claims4
A compound of general formula (I) below:
- in which:
- R1 represents:
- a C1-C5 alkyl radical,
- a C3-C6 cycloalkyl radical,
- an aryl radical,
- a substituted aryl radical,
- an aralkyl radical,
- a C1-C5 alkoxy radical,
- an amino radical corresponding to structure (a):
- in which R2 represents:
- a hydrogen,
- a C1-C5 alkyl radical,
- a C3-C6 cycloalkyl radical,
- an aryl radical,
- a substituted aryl radical,
- a pyridyl radical,
- an aralkyl radical,
- a radical corresponding to structure (b):
- in which p can have the value 1 or 2,
- a radical corresponding to structure (c):
- in which R4 represents:
- a carboxymethyl —COOCH3 or carboxyethyl —COOEt radical,
- a C1-C3 alkyl radical,
- a hydrogen,
- and R5 represents:
- a substituted or unsubstituted aryl radical,
- a C3-C6 cycloalkyl radical,
- a pyridyl,
- and R3 represents:
- a hydrogen,
- a C1-C5 alkyl radical;
- or R1 may also represent a radical corresponding to formula (d):
- in which R6 represents:
- a hydrogen,
- a C1-C5 alkyl radical,
- a C3-C6 cycloalkyl radical,
- an aryl radical,
- a substituted aryl radical,
- a pyridyl radical,
- an aralkyl radical,
- R7 represents:
- a hydrogen,
- a C1-C5 alkyl radical,
- and R8 represents:
- a hydrogen,
- a hydroxyl,
- an amino radical,
- a C1-C3 alkoxy radical;
- Y represents a hydrogen or a fluorine, and
- m and n can have the value 0, 1 or 2,
- and also salts of the compounds of formula (I), and enantiomer forms thereof.
48 more elements
Dependencies are inferred from the claim text.