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US 8,299,257 B2Granted
Compounds which have activity at M1receptor and their uses in medicine
AssigneeGlaxo Group Limited
InventorsDavid Gwyn Cooper, Ian Thomson Forbes, Vincenzo Garzya, Dale James Johnson, Graeme Irvine Stevenson, Paul Adrian Wyman
Life of this patent
Estimating the term…
Abstract
Compounds of formula (I) or a salt thereof are provided: wherein R4, R5, R6, Q, A, Y and R are as defined in the description. Uses of the compounds as medicaments and in the manufacture of medicaments for treating psychotic disorders, cognitive impairments and Alzheimer's Disease are disclosed. The invention further discloses pharmaceutical compositions comprising the compounds.
Claims20
A compound of formula (I) or a salt thereof:
- wherein:
- R4, R5 and R6 are independently selected from hydrogen, halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, cyano, C1-6alkylsulfonyl, C1-6alkylsulfonyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C1-6alkoxy, C1-6alkoxy substituted with one or more fluorine atoms, C1-6alkanoyl, —C(═NOC1-6alkyl)C1-6alkyl, —C1-6alkoxyC1-6alkyl, and —C(O)NRaRb;
- Ra and Rb are each independently H or C1-6 alkyl, or together with the nitrogen atom to which they are attached form a five or six membered ring;
- ring A represents a benzene ring, or a 6-membered aromatic heterocylic ring containing one or two nitrogen atoms;
- R is selected from C3-6cycloalkylC1-4-alkyl, C1-6alkyloxyC1-6alkyl, C3-6cycloalkyloxyC1-6alkyl and C3-6cycloalkylC1-4alkyloxyC1-6alkyl, wherein any alkyl or cycloalkyl group is optionally substituted by one or more fluorine atoms;
- Q is selected from hydrogen and C1-6alkyl;
- and
- Y is selected from O, S, CF2, CH2CH2, OCH2, and CH2O.
5 more elements
Dependencies are inferred from the claim text.