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US 8,299,254 B2Granted
Preparation of pyridonecarboxylic acid antibacterials
AssigneeAbbott Laboratories
InventorsAnthony Haight, David M. Barnes, Geoff G. Z. Zhang
Life of this patent
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Abstract
A process for making 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid, and therapeutically acceptable salts thereof, and intermediates used in the process are disclosed.
Claims19
A process for making 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid or a salt thereof, comprising:
- (k) reacting ethyl 1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-7-(3-(isobutyryloxy)azetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate or a salt thereof and a chlorinating agent and isolating or not isolating the product;
- and (1) reacting the product of step (k) and a hydroxide base.
Dependencies are inferred from the claim text.