Method for producing camptothecin derivatives
AssigneesSichuan Xieli Pharmaceutical Co., Ltd., Microbiopharm Japan Co., Ltd.
InventorsAsako Toyoda, Hazuki Nagai, George Ng'ang'a Wanyoike
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Abstract
The invention offers a method of hydrogenating camptothecin in inert solvent in the presence of nickel catalyst, whereby selective hydrogenation of camptothecin can be very efficiently accomplished using the low-cost catalyst.
Claims8
A method comprising reduction of a compound represented by the following formula (I) to produce the corresponding 1,2,6,7-tetrahydro compound represented by the following formula (II), comprising a step of contacting a compound of the formula (I) with hydrogen in an inert solvent, in the presence of a nickel catalyst as a hydrogenation catalyst:
- in the formulae, R stands for an atom or an atomic group selected from the group consisting of hydrogen atom and C1-C6 alkyl groups.
Dependencies are inferred from the claim text.