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US 8,299,245 B2Granted
Method for producing pyrimidine compound
AssigneeSumitomo Chemical Company, Limited
InventorMichihiko Fujinami
Life of this patent
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Abstract
A 4-amino-6-alkynyloxypyrimidine compound, which is represented by the formula (I) and has an effect of controlling a harmful organism, can be produced in a high yield by reacting a 4,6-difluoropyrimidine compound with an alkynol compound in an alkyl benzene in the presence of an organic salt and potassium carbonate and reacting the resulting compound with an amine compound without isolating the resulting compound.
Claims6
A method for producing a 4-amino-6-alkynyloxypyrimidine compound (I) represented by the formula (I):
- wherein R1, R2, R3 and R4 are as defined below,
- which comprises reacting a compound (II) represented by the formula (II):
- wherein R1 represents a hydrogen atom or a halogen atom, with a compound (III) represented by the formula (III):
- wherein R2 represents a hydrogen atom or a methyl group,
- in the presence of an organic base and potassium carbonate, in an alkylbenzene to give a compound (IV) represented by the formula (IV):
- wherein R1 and R2 are as defined above, and the compound (IV) being without performing isolation, and then reacting the resultant compound (IV) with a compound (V) represented by the formula (V) or a salt thereof:
- wherein R3 and R4 are combined to form a C4-C7 polymethylene group, in which the C4-C7 polymethylene group may be substituted with one or more substituents selected from the group consisting of a halogen atom, a lower alkyl group substituted with halogen atom(s) and a lower alkyl group.
4 more elements
Dependencies are inferred from the claim text.