Back to results
US 8,299,215 B2Granted
Methods and compositions for treating brain diseases
AssigneeUniversity of Iowa Research Foundation
InventorsBeverly L. Davidson, Yong Hong Chen
Life of this patent
Estimating the term…
Abstract
The present disclosure provides targeting peptides and vectors containing a sequence that encodes targeting peptides that deliver agents to the brain.
Claims9
A modified adeno-associated virus (AAV) capsid protein comprising a targeting peptide, wherein the targeting peptide is from 3 to 10 amino acids in length and wherein the targeting peptide targets an AAV to brain vascular endothelium, wherein the targeting peptide is GMNAFRA (SEQ ID NO:41), as expressed in an amino to carboxy orientation or in a carboxy to amino orientation.
Dependencies are inferred from the claim text.