Acetone-soluble, absorbable, crystalline polyaxial copolymers and applications thereof
AssigneePoly-Med, Inc.
InventorsShalaby W. Shalaby, James M Lindsey, Christof Merckle, Helmut Goldmann
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Abstract
High-purity, acetone-soluble, absorbable components of medical devices are designed for optimum interfacing with human blood or the cell lining of a body cavity, and are formed of a crystalline, segmented l-lactide polyaxial copolymer structurally tailored to have certain molecular dimensions, thermal and physicomechanical properties, and solubility characteristics to allow their uses, optimally, as parts of vascular, urological, and post-surgical adhesion prevention devices.
Claims9
An acetone-soluble, absorbable polymer as a component of a medical device capable of beneficially interfacing with human blood and with the cell lining of a body cavity, the polymer comprising a film-forming, electrostatically spinnable, crystalline, segmented, 1-lactide polyaxial copolyester made by end-grafting a monocentric polyaxial polymeric initiator with a mixture of cyclic monomers, thereby covalently bonding crystallizable terminal segments onto an amorphous core, the amorphous core having a glass transition temperature below 37° C., the copolyester having a minimum solubility of 2 percent weight/volume in acetone, an inherent viscosity in chloroform of more than about 1.0 dL/g, a melting temperature of more than about 100° C., a heat of fusion of up to about 20 J/g, a shore-A hardness of less than about 100, and an ultimate elongation of greater than about 100 percent in film form.
Dependencies are inferred from the claim text.