Water-soluble triterpenephenol compounds having antitumor activity and the preparation thereof
AssigneeShanghai Huatuo Medical Science Co., Ltd
InventorsJiafeng Zeng, Junfang Pan, Baoying Li, Qin Zhu, Tong Fang, Huiyan Ni
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Abstract
The invention discloses water-soluble triterpenephenol compounds having antitumor activity represented by formula (I), wherein the substituents R1˜R4 and M are defined as in the description. The invention also discloses a method for preparing the compounds of formula (I) used quinone methide triterpene compounds as starting materials. The water-soluble triterpenephenol compounds disclosed in the invention can be made into various dosage forms including injection, tablet, capsule, granule and liniment, particularly suitable for making into injection.
Claims9
A water-soluble triterpenephenol compound represented by the following formula:
- wherein,
- R2=H, C1-C12 alkyl or C1-C12 acyl;
- M=Na, K, NH4 or ½Ca;
- R1=H or C1-C12 alkyl;
- R3 and R4 are H or OH, or R3 is H, and R4 is (O═), or the carbon atoms at the 7- and 8-positions where R4 and R3 are respectively located form a double bond.
Dependencies are inferred from the claim text.