Method for stabilizing retinoic acid, retinoic acid containing composition, and method of using a retinoic acid containing composition
AssigneeSkinvisible Pharmaceuticals, Inc.
InventorJames A. Roszell
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Abstract
A method for stabilizing retinoic acid is provided. The method includes a step of mixing retinoic acid with a hydrophobic polymer/hydrophilic polymer adduct in the presence of an oxygen containing atmosphere to form a retinoic acid containing composition. The hydrophobic polymer/hydrophilic polymer adduct comprises a poly(vinylpyrrolidone/alkylene) polymer and a polymer comprising repeating carboxylic acid groups, hydroxyl groups, or a mixture of carboxylic acid groups and hydroxyl groups. A retinoic acid containing composition and a method of using a retinoic acid containing composition are provided.
Claims24
A method for stabilizing retinoic acid, the method comprising:
- mixing retinoic acid with a hydrophobic polymer/hydrophilic polymer adduct comprising a poly(vinylpyrrolidone-alkylene) polymer and cellulose to form a retinoic acid containing composition comprising about 0.01 wt. % to about 0.15 wt. % of the retinoic acid, wherein the step of mixing comprises mixing in the presence of an oxygen containing atmosphere, wherein the retinoic acid containing composition retains at least about 70% of its original activity after accelerated testing at 40° C. for 120 days with exposure to an oxygen atmosphere.
A retinoic acid containing composition comprising:
- (a) at least about 0.0001 wt. % retinoic acid;
- (b) at least about 3 wt. % of a hydrophobic polymer/hydrophilic polymer adduct comprising a poly(vinylpyrrolidone-alkylene) polymer and cellulose;
- (c) at least about 50 wt. % water;
- (d) wherein the retinoic acid containing composition retains at least about 70% of its original activity after accelerated testing at 40° C. for 120 days with exposure to an oxygen atmosphere, and
- (e) wherein the composition is made by mixing the polyvinylpyrrolidone-alkylene) polymer, cellulose, and retinoic acid in the presence of an oxygen containing atmosphere.
Dependencies are inferred from the claim text.