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US 8,299,119 B2Granted
Biologically active compounds
AssigneeBio-Active Export Pty. Ltd.
InventorsDavid Leach, Lesley Stevenson, Brigitte Gabriel, Karren Beattie
Life of this patent
Estimating the term…
Abstract
Compounds having useful biological activity, particularly antioxidant and anti-inflammatory activity, derived from Centipeda cunninghamii, and biologically active derivatives thereof, pharmaceutical compositions comprising these compounds, and prophylactic and therapeutic use of the compounds.
Claims11
An isolated compound of Formula II:
- wherein each R, which may be the same or different, is selected from the group consisting of hydrogen and R1;
- and
- each R1, which may be the same or different, is selected from the group consisting of substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylarlkyl, a protecting group, —C(O)—Ra, —C(O)O—Ra, —C(O)NRaRa, —S(O)n—NRaRa (wherein n represents 1 or 2, and Ra is selected from the group consisting of hydrogen and substituted or unsubstituted alkyl);
- and their pharmaceutically acceptable salts.
1 more element
A compound selected from:
- i. 4ξ,5ξ-Di-O-caffeoyl-2,6ξ-dihydroxyhept-2-en-1,7-dioic acid (Compound 2)
- ii. 4ξ,5ξ-Di-O-caffeoyl-2,6ξ-dihydrodyhept-2-en-1,7-dioic acid-7-methyl ester (Compound 8)
- iii. 4ξ,5ξ-Di-O-caffeoyl-2,6ξ-dihydroxyhept-2-en-1,7-dioic acid-1-methyl ester (Compound 9)
- iv. 4ξ,5ξ-Di-O-caffeoyl-2,6ξ-dihydroxyhept-2-en-1,7-dioic acid-dimethyl ester (Compound 10)
- in substantially purified form, and pharmaceutically acceptable salts thereof.
2 more elements
Dependencies are inferred from the claim text.