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US 8,299,112 B2Granted
Estrogen receptor modulators and uses thereof
AssigneeAragon Pharmaceuticals, Inc.
InventorsNicholas D. Smith, Mehmet Kahraman, Steven P. Govek, Johnny Y. Nagasawa, Andiliy G. Lai, Jackaline D. Julien, Celine Bonnefous
Life of this patent
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Abstract
Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
Claims12
A compound of Formula (I), or a pharmaceutically acceptable salt, or N-oxide thereof:
- wherein,
- Z is —OH or —OR10;
- R2 is C1-C4alkyl, C1-C4-fluoroalkyl, C1-C4deuteroalkyl, C3-C6cycloalkyl, or —C1-C4alkylene-W;
- W is hydroxy, halogen, CN, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy, or C3-C6cycloalkyl;
- each R3 is independently halogen, C1-C4alkyl, or C1-C4-fluoroalkyl;
- each R4 is independently halogen, —CN, —OR9, —S(═O)2R10, C1-C4alkyl, C1-C4-fluoroalkyl, or C1-C4heteroalkyl;
- each R5 is independently halogen, —CN, —OR9, —S(═O)2R10, C1-C4alkyl, C1-C4-fluoroalkyl, or C1 C4heteroalkyl;
- R6 is H, C1-C4alkyl, or halogen;
- R7 is H, C1-C4alkyl, or halogen;
- R9 is H, C1-C6alkyl, C1-C6-fluoroalkyl, or C3-C6cycloalkyl;
- R10 is C1-C6alkyl;
- m is 0, 1, or 2;
- n is 0, 1, 2, 3, or 4;
- and
- p is 0, 1, or 2.
12 more elements
Dependencies are inferred from the claim text.