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US 8,299,100 B2Granted
Potent and selective neuronal nitric oxide synthase inhibitors with improved membrane permeability
AssigneeNorthwestern University
InventorsRichard B. Silverman, Fengtian Xue
Life of this patent
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Abstract
Compounds and related compositions and methods as can be used to inhibit neuronal nitric oxide synthase and can be employed in the treatment of various neurodegenerative diseases, such compounds of a formula
Claims22
A nitric oxide synthase inhibitor compound of a formula
- wherein X is selected from divalent ethylene oxide, cyclopropyl, monofluoroethylene and difluoroethylene moieties;
- and Φ is selected from phenyl, substituted phenyl, piperidinyl and substituted piperidinyl moieties, or a salt thereof.
A nitric oxide synthase inhibitor compound of a formula
- wherein X is selected from divalent ethylene oxide, cyclopropyl, monofluoroethylene and difluoroethylene moieties;
- and Φ is selected from phenyl, substituted phenyl, piperidinyl and substituted piperidinyl moieties, or a salt thereof wherein the pyridine of said compound is at least partially reduced.
A nitric oxide synthase inhibitor compound of a formula
- wherein R is selected from H, halide and alkyl moieties;
- or a salt thereof.
A method inhibiting a nitric oxide synthase comprising contacting a nitric oxide synthase with an effective amount of a compound of a formula
- wherein X is selected from divalent ethylene oxide, cyclopropyl, monofluoroethylene and difluoroethylene moieties;
- and Φ is selected from phenyl, substituted phenyl, piperidinyl and substituted piperidinyl moieties, or a salt thereof.
Dependencies are inferred from the claim text.