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US 8,299,095 B2Granted
Crystalline forms of 4-[2-(4-methylphenylsulfanyl)-phenyl] piperidine with combined serotonin and norepinephrine reuptake inhibition and uses thereof
AssigneeH. Lundbeck A/S
InventorsBenny Bang-Andersen, Andre Faldt, Tine Bryan Stensbol, Silke Miller, Heidi Lopez De Diego
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Abstract
Crystalline forms of 4-[2-(4-methylphenylsulfanyl)-phenyl]piperidine and salts thereof are provided e.g. for the treatment of neuropathic pain.
Claims18
Compound I, which is 4-[2-(4-methylphenyl-sulfanyl)phenyl]piperidine
- and pharmaceutically acceptable salts thereof in a crystalline form selected from the group consisting of an:
- HBr addition salt in a crystalline form characterized by peaks in an XRPD at 6.08, 14.81, 19.26 and 25.38+/−0.10° 2θ;
- DL-lactic acid addition salt in a crystalline form characterized by peaks in an XRPD at 5.30, 8.18, 9.44 and 17.24+/−0.10° 2θ;
- glutaric acid addition salt (1:1) in a crystalline form characterized by peaks in an XRPD at 9.39, 11.70, 14.05 and 14.58+/−0.10° 2θ;
- and
- glutamic acid addition salt (1:1) in a crystalline form characterized by peaks in an XRPD at 7.71, 14.01, 19.26 and 22.57+/−0.10° 2θ.
3 more elements
Dependencies are inferred from the claim text.