Thiazolyl-and oxazolyl-isoquinolinones and methods for using them

A compound of Formula I:

• wherein:
• X is C1-C9 alkylene, C2-C9 alkenylene, or C2-C9 alkynylene;
• Y is O or S;
• R1 is hydrogen, hydroxy, or OR7;
• R2, R3, and R4 are independently hydrogen;
• R5 and R6 are each, independently, C1 C6 alkyl, wherein the alkyl is optionally substituted with one or more groups selected from hydroxy, C1-C4 alkoxy, —CO2H, C1-C6 alkoxycarbonyl, NH2, C1-C6 mono- or dialkylamino, and halogen;
• or
• R5 and R6 together with the nitrogen to which they are attached form a saturated, partially unsaturated, or unsaturated 3 to 12 membered monocyclic or bicyclic heterocyclic ring optionally comprising from one to three additional ring heteroatoms selected from N, O, and S, and the remainder of the ring atoms are carbon atoms;
• R7 is C1-C6 alkyl, C2-C6 alkenyl, or C3-C7 cycloalkyl wherein the alkyl, alkenyl, and rings of the cycloalkyl are optionally substituted with one or more groups selected from hydroxy, C1-C4 alkoxy, —CO2H, C1-C6 alkoxycarbonyl, NH2, C1-C6 mono- or dialkylamino, and halogen;
• or a pharmaceutically acceptable salt form thereof.